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Development of chromatographic fingerprinting and its related chemometric methods in the research of quality control of traditional Chinese medicines (TCMs) are discussed. The quality control methods for guarantying the authentica...
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Development of chromatographic fingerprinting and its related chemometric methods in the research of quality control of traditional Chinese medicines (TCMs) are discussed. The quality control methods for guarantying the authentication and stability of products and semi-products of TCMs are firstly assessed. The technique based on chromatographic fingerprinting is essentially a kind of high-throughput and integral tools to explore the complexity of herbal medicines. In order to further control the comprehensive quality of TCMs, confirmation and identification of their important chemical components are necessary. Some new strategies are proposed to trace the chemical changes of chromatographic fingerprints both in product processing and/or after their administration by modern chromatographic techniques and chemometrics. Combined with systems biology and bioinformatics, it seems possible for one to reveal the working mechanism of TCMs and to further control their intrinsic quality comprehensively.
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Traditional Chinese medicine (TCM), the ancient medicine popular in China and surrounding areas, has been recognized as a typical representative of complementary and alternative medicine. Over long period in clinical practice, esp...
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Traditional Chinese medicine (TCM), the ancient medicine popular in China and surrounding areas, has been recognized as a typical representative of complementary and alternative medicine. Over long period in clinical practice, especially the progress in basic research, data on the effectiveness and beneficial contribution of TCM herbs to public health and disease control have been accumulated while the quality of the evidence is generally poor. The most common clinical practice of TCM herbs is herb combination called formula which consists of several types of medicinal herbs or minerals, which is quite different from modern medicine. Definitely, tens of hundreds of compounds could be identified in even a small formula. With the regained enthusiasm on natural products based new drug R&D, the proposed multi-target drug discovery strategy, the booming of -omics technologies, and the implementation of ambitious plan of TCM modernization in China, attempts have been made to fill the gap between TCM herbs and modern drugs. However, are we heading to the right direction?.
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Ethnobotany in China is being widely used for the documentation of indigenous knowledge about the usage of plants and inventorising plants that have been used in Traditional Chinese Medicine (TCM) since 3,000 BC. In recent years, ...
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Ethnobotany in China is being widely used for the documentation of indigenous knowledge about the usage of plants and inventorising plants that have been used in Traditional Chinese Medicine (TCM) since 3,000 BC. In recent years, the latter has becomean important part of ethnobotanical studies. Recent approaches towards TCM development in China have shifted from inheritance to modernization. This has brought forth great opportunities and challenges to the TCM and medicinal plants as well. The paperdiscusses some ethnobotanical aspects of traditional medicine in relation to development of new drugs and modernization of TCM in China.
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Introduction: There is no study exploring the trend of utilization in traditional Chinese medicine (TCM) from 2000 to 2010. The objective of this study was to investigate the trends of TCM utilization among 3 cross-sectional cohor...
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Introduction: There is no study exploring the trend of utilization in traditional Chinese medicine (TCM) from 2000 to 2010. The objective of this study was to investigate the trends of TCM utilization among 3 cross-sectional cohorts of 2000, 2005, and 2010.
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Traditional Chinese medicine (TCM) for anti-abortion is based on the theory of gynecology of TCM, which aims to prevent and treat abdominal pain during pregnancy, fetal leakage, uneasy fetal movement, and fetal atrophy. Because of...
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Traditional Chinese medicine (TCM) for anti-abortion is based on the theory of gynecology of TCM, which aims to prevent and treat abdominal pain during pregnancy, fetal leakage, uneasy fetal movement, and fetal atrophy. Because of the complexity of the ingredients of Chinese Materia Medica, and the imprecise intervention mechanism for tocolysis, further investigation about the effects of Chinese herbs and their components on tocolysis by utilizing advanced technologies is required to be made. All the information available about TCM and its effects on pregnant women and fetuses was collected via electronic search using Web of Science, PubMed, and CNKI, and a library search was performed to locate classic herbal medicine books. The active ingredients in TCM were screened with the help of Traditional chinese medicine systems pharmacology database and analysis platform (TCMSP). The keywords being used included herbal names, pharmacology, pregnancy, threatened abortion, and fetus. Modern pharmacological studies have shown that TCM mainly prevents threatened abortion by a direct effect on the pregnant woman's immune system, sex hormones such as estrogen and progesterone, the uterus and the endometrium, and the decidual tissue such as the placenta. It may also address pregnancy complications due to advanced maternal age, infection, polycystic ovary syndrome, diabetes, and mental disorders caused by threat of a miscarriage. TCM protects against spontaneous miscarriage, but its mechanisms are largely unknown. This research applies scientific methods to characterize and examine the effective components of TCM and their application to lower the risk of abortion to the pregnant women and fetuses.
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Since the introduction of domestic antivenom in the 1970s and 1980s, with the improvement of medical conditions in China after the reform and opening up, it has basically achieved popularization from the 1990s to the first few yea...
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Since the introduction of domestic antivenom in the 1970s and 1980s, with the improvement of medical conditions in China after the reform and opening up, it has basically achieved popularization from the 1990s to the first few years of the 21st century. However, with the establishment of the socialist market economy and the completion of the medical and health reforms, the supply of antivenoms, which were originally sufficient, began to be in short supply. In order to solve the supply problem of shortage drugs such as antivenom, the national and local health authorities have carried out beneficial explorations to establish a shortage drug guarantee mechanism. The academic circle has also restarted the research on traditional Chinese medicine snakebite preparations and antivenoms that have been completed in the 20th century, and has been establishing provincial and municipal snakebite treatment centers and cross-regional snakebite treatment bases, conducting international snakebite treatment and making research collaborations to actively respond to the current shortage of antivenoms.Since entering the 21st century, the problem of poisonous snakebite has retreated in a secondary position in the medical community, and the research on progress in this area has basically no longer attracted the attention of the academic community. In fact, the tension of contemporary snake bite medical resources is not only domestic, but also showing a stronger status quo in the world, and is becoming a medical problem that cannot be ignored. This article uses the time-delayed research method, systematically combing the repeated fluctuations of anti -snake -toxic serum supply before 2000 to these years, as well as the relevant historical facts of the re-development and application of drugs such as traditional Chinese medicine snakebite preparations for alternatives. The attention of the academic and relevant departments attracted the attention of this issue, and the early prevention of snake bite in order to take into account the "green water and green mountains"policy and ensure the health of the people's lives are hoped to be taken.
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Traumatic brain injury (TBI) is the leading cause of disability and death, and the social burden of mortality and morbidity caused by TBI is significant. Under the influence of comprehensive factors, such as social environment, li...
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Traumatic brain injury (TBI) is the leading cause of disability and death, and the social burden of mortality and morbidity caused by TBI is significant. Under the influence of comprehensive factors, such as social environment, lifestyle, and employment type, the incidence of TBI continues to increase annually. Current pharmacotherapy of TBI mainly focuses on symptomatic supportive treatment, aiming to reduce intracranial pressure, ease pain, alleviate irritability, and fight infection. In this study, we summarized numerous studies covering the use of neuroprotective agents in different animal models and clinical trials after TBI. However, we found that no drug has been approved as specifically effective for the treatment of TBI. Effective therapeutic strategies for TBI remain an urgent need, and attention is turning toward traditional Chinese medicine. We analyzed the reasons why existing high-profile drugs had failed to show clinical benefits and offered our views on the research of traditional herbal medicine for treating TBI.
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Depression is a common psychiatric disorder and a leading cause of disability worldwide. Traditional Chinese medicine is one of the commonly used complementary and alternative medicine therapies for depression. Clinical trials hav...
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Depression is a common psychiatric disorder and a leading cause of disability worldwide. Traditional Chinese medicine is one of the commonly used complementary and alternative medicine therapies for depression. Clinical trials have been carried out to assess the efficacy and safety of Chinese herbal medicine currently. The exploration of herbal mechanisms of action used for the treatment of depression has also received great attention. This study is performed to summarize the frequently used formulae, patent drugs and single herbs in treating depression, review the literatures of clinical trials in treating depressive disorders, and to list the possible mechanisms involved during the treatment. Besides, we will analyze the limitations of present studies and the obstacles in the modernization of traditional Chinese medicine.
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The key issues in the modernization of Traditional Chinese Medicine (TCM) are (1) standardization of TCM products and (2) clinical efficacy and safety. Scientific data from well designed studies pertaining to these 2 areas are nee...
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The key issues in the modernization of Traditional Chinese Medicine (TCM) are (1) standardization of TCM products and (2) clinical efficacy and safety. Scientific data from well designed studies pertaining to these 2 areas are needed to address these 2 issues and gain international recognition of TCM. Proper pharmacokinetic studies can be very helpful as they can provide useful data not only to support efficacy and safety, but can potentially contribute to in vivo standardization of TCM. There are 3 aspects which pharmacokinetic studies can contribute to modernizations of TCM: (1) For an orally administered TCM, absorption studies are important to provide data to support clinical efficacy or planning of clinical trials. Since a given TCM contains multiple ingredients, the absorption of various ingredients that relate to activity will be important consideration. (2) Pharmacokinetic interactions can occur among different components in a TCM product and such components can also cause interactions with western drugs, hence studies on interactions will be useful for optimizing efficacy and safety of TCM. (3) Pharmacokinetic studies, together with well-developed analytical techniques, can potentially provide a method for in vivo standardization of TCM. Examples of pharmacokinetic studies of TCM involving absorption and interaction and the idea of in vivo standardization will be discussed.
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